Atherosclerosis Supplements
Volume 10, Issue 5 , Pages 95-101 , 29 December 2009

Fibrinogen/LDL apheresis as successful second-line treatment of sudden hearing loss: a retrospective study on 217 patients

  • Franz Heigl

      Affiliations

    • Dres. Heigl, Hettich & Partner, Medizinisches Versorgungszentrum Kempten-Allgäu, Kempten, Germany
    • Corresponding Author InformationMedizinisches Versorgungszentrum Kempten-Allgäu, Robert-Weixler-Straβe 9, 87439 Kempten, Germany. phone: +49-831-570577-10; fax: +49-831-570577-51
    • ,
  • Reinhard Hettich

      Affiliations

    • Dres. Heigl, Hettich & Partner, Medizinisches Versorgungszentrum Kempten-Allgäu, Kempten, Germany
    • ,
  • Markus Suckfuell

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich, Germany
    • ,
  • Christian W. Luebbers

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Dachau, Germany
    • ,
  • D. Osterkorn

      Affiliations

    • Medizinisches Wirtschaftsinstitut, Munich, Germany
    • ,
  • K. Osterkorn

      Affiliations

    • Medizinisches Wirtschaftsinstitut, Munich, Germany
    • ,
  • Martin Canis

      Affiliations

    • Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich, Germany

References 

  1. Olzowy B , Osterkorn D , Suckfuell M . The incidence of sudden hearing loss is greater than previously assumed . MMW. Fortschr. Med. . 2005;147:37–38
  2. Miller JM , Ren TY , Nuttall AL . Studies of inner ear blood flow in animals and human beings . Otolaryngol. Head Neck Surg. . 1995;112:101–113
  3. Sidman JD , Prazma J , Pulver SH , Pillsbury HC . Cochlea and heart as end-organs in small vessel disease . Ann. Otol. Rhinol. Laryngol. . 1988;97:9–13
  4. Feron O , Dessy C , Desager JP , Balligand JL . Hydroxy-methylglutarylcoenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance . Circulation . 2001;103:113–118
  5. Nguyen TV , Brownell WE . Contribution of membrane cholesterol to outer hair cell lateral wall stiffness . Otolaryngol. Head Neck Surg. . 1998;119:14–20
  6. Suckfuell M , Seidel D , Thiery J , et al.   [Treatment of sudden hearing loss through Fibrinogen/LDL-apheresis. A prospective, randomized multicenter trial] . Z. Kardiol . 2003;92:III59–III63
  7. Suzuki K , Kaneko M , Murai K . Influence of serum lipids on auditory function . Laryngoscope . 2000;110:1736–1738
  8. Suckfuell M . Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial . Lancet . 2002;360:1811–1817
  9. Axelsson A , Lindgren F . Is there a relationship between hyper- cholesterolaemia and noise-induced hearing loss? . Acta Otolaryngol. . 1985;100:379–386
  10. Preyer S , Baisch A , Bless D , Gummer AW . Distortion product oto- acoustic emissions in human hypercholesterolemia . Hear. Res. . 2001;152:139–151
  11. Rosen S , Bergman M , Plester D , EL Mofty A , Satti MH . Presbycusis study of a relatively noise-free population in the Sudan . Trans. Am. Otol. Soc. . 1962;50:135–152
  12. Morizono T , Paparella MM . Hypercholesterolemia and auditory dys- function. Experimental studies . Ann. Otol. Rhinol. Laryngol. . 1978;87:804–814
  13. Syka J , Ouda L , Nachtigal P , Solichova D , Semecky V . Atorvastatin slows down the deterioration of inner ear function with age in mice . Neurosci. Lett. . 2007;411:112–116
  14. Cunningham DR , Goetzinger CP . Extra-high frequency hearing loss and hyperlipidemia . Audiology . 1974;13:470–484
  15. Morizono T , Sikora MA , Ward WD , Paparella MM , Jorgensen J . Hyperlipidemia and noise in the chinchilla . Acta Otolaryngol . 1985;99:516–524
  16. Saito T , Sato K , Saito H . An experimental study of auditory dys- function associated with hyperlipoproteinemia . Arch. Otorhinolaryngol. . 1986;243:242–245
  17. Gratton MA , Wright CG . Alterations of inner ear morphology in experimental hypercholesterolemia . Hear. Res. . 1992;61:97–105
  18. Fessenden JD , Schacht J . The nitric oxide/cyclic GMP pathway: a potential major regulator of cochlear physiology . Hear. Res. . 1998;118:168–176
  19. Ciuffetti G , Scardazza A , Serafini G , Lombardini R , Mannarino E , Simoncelli C . Whole-blood filterability in sudden deafness . Laryngoscope . 1991;101:65–67
  20. Ohinata Y , Makimoto K , Kawakami M , Haginomori S , Araki M , Takahashi H . Blood viscosity and plasma viscosity in patients with sudden deafness . Acta Otolaryngol. . 1994;114:601–607
  21. Ernst E , Resch KL . Fibrinogen as a cardiovascular risk factor: a meta- analysis and review of the literature . Ann. Intern. Med. . 1993;118:956–963
  22. Liberman MC , Gao J , He DZ , Wu X , Jia S , Zuo J . Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier . Nature . 2002;419:300–304
  23. Zheng J , Shen W , He DZ , Long KB , Madison LD , Dallos P . Prestin is the motor protein of cochlear outer hair cells . Nature . 2000;405:149–155
  24. Rajagopalan L , Greeson JN , Xia A , et al.   Tuning of the outer hair cell motor by membrane cholesterol . J. Biol. Chem. . 2007;282:36659–36670
  25. Sturm AK , Rajagopalan L , Yoo D , Brownell WE , Pereira FA . Functional expression and microdomain localization of prestin in cultured cells . Otolaryngol. Head Neck Surg. . 2007;136:434–439
  26. Ohvo-Rekila H , Ramstedt B , Leppimaki P , Slotte JP . Cholesterol interactions with phospholipids in membranes . Prog. Lipid Res. . 2002;41:66–97
  27. Starke-Peterkovic T , Turner N , Vitha MF , Waller MP , Hibbs DE , Clarke RJ . Cholesterol effect on the dipole potential of lipid membranes . Biophys. J. . 2006;90:4060–4070
  28. Wei BP , Mubiru S , O'Leary S . Steroids for idiopathic sudden sensori- neural hearing loss . Cochrane. Database. Syst. Rev. . 2006; CD003998
  29. Mattox DE , Simmons FB . Natural history of sudden sensorineural hearing loss . Ann. Otol. Rhinol. Laryngol. . 1977;86:463–480
  30. Wilson WR , Byl FM , Laird N . The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study . Arch. Otolaryngol. . 1980;106:772–776
  31. Probst R , Tschopp K , Ludin E , Kellerhals B , Podvinec M , Pfaltz CR . A randomized, double-blind, placebo-controlled study of dextran/ pentoxifylline medication in acute acoustic trauma and sudden hearing loss . Acta Otolaryngol. . 1992;112:435–443
  32. Alexiou C , Arnold W , Fauser C , et al.   Sudden sensorineural hearing loss: does application of glucocorticoids make sense? . Arch. Otolaryngol. Head Neck Surg. . 2001;127:253–258
  33. Pfefferkorn TK , Knuppel HP , Jaeger BR , Thiery J , Hamann GF . Increased cerebral CO(2) reactivity after heparin-mediated extra- corporal LDL precipitation (HELP) in patients with coronary heart disease and hyperlipidemia . Stroke . 1999;30:1802–1806
  34. Mellwig KP , van Buuren F , Schmidt HK , Wielepp P , Burchert W , Horstkotte D . Improved coronary vasodilatatory capacity by H.E.L.P. apheresis: comparing initial and chronic treatment . Ther. Apher. Dial. . 2006;10:510–517
  35. Kojima Y , Ito S , Furuya N . Hearing improvement after therapy for hyperlipidemia in patients with chronic-phase sudden deafness . Ann. Otol. Rhinol. Laryngol. . 2001;110:105–108
  36. Seidel D . H.E.L.P. apheresis therapy in the treatment of severe hyper-cholesterolemia: 10 years of clinical experience . Artif. Organs . 1996;20:303–310
  37. Shiraishi T , Kubo T , Okumura S , et al.   Hearing recovery in sudden deafness patients using a modified defibrinogenation therapy . Acta Otolaryngol Suppl . 1993;501:46–50
  38. Canis M , Heigl F , Hettich R , Osterkorn D , Osterkorn K , Suckfuell M . [Fibrinogen/LDL apheresis for treatment of sudden hearing loss: an observational study on 152 patients] . HNO . 2008;56:961–966

PII: S1567-5688(09)71820-3

doi: 10.1016/S1567-5688(09)71820-3

Atherosclerosis Supplements
Volume 10, Issue 5 , Pages 95-101 , 29 December 2009

Article Tools